A patient is referred to you from the medical clinic because of an oral problem provided in the image below. The patient states that he has had bleeding while brushing for a few weeks but otherwise has no symptoms. What should be asked in his medical history to determine the cause?

1.Do you have a history of seizures?
2.Are you being treated for diabetes mellitus?
3.Have you been treated for cancer recently?
4.Do you have renal failure?

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