Published on Aug 11, 2020
Clinical Scenario

A 65-year-old male with chronic renal failure has been on maintenance hemodialysis for the past 20 years. On physical examination, there is atrophy of the thenar muscles of the right hand. There is decreased sensation in his right thumb, middle, index, and ring fingers due to deposition of a material in the carpel tunnel causing compression of nerves. Which of the following is the most likely deposit ?

1.Accumulation of serum amyloid protein
2.Hyperkalemia
3.Accumulation of beta-2 microglobulin
4.Decreased uric acid excretion

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