Malaria Life Cycle

The malaria parasite life cycle involves two hosts. During a blood meal, a malaria-infected female Anopheles mosquito inoculates sporozoites into the human host

•  . Sporozoites infect liver cells  and mature into schizonts , which rupture and release merozoites .
• After this initial replication in the liver (exo-erythrocytic schizogony ), the parasites undergo asexual multiplication in the erythrocytes (erythrocytic schizogony ). Merozoites infect red blood cells . 
• The ring stage trophozoites mature into schizonts, which rupture releasing merozoites . 
•  . Blood stage parasites are responsible for the clinical manifestations of the disease.

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